In my experience Acunetix has failed miserably; it has flagged a lot of crap that is really a non-issue, given me a lot of false positives and not found any results.
[EDIT]: To be fair I was using a warez copy, so it was probably a bit out of date, but still, it didn't find anything I cared about, anywhere. And I gave it plenty of chances against different platforms and targets.
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Edited 1 time(s). Last edit at 10/23/2008 11:57PM by kuza55.